The DataFrame class comes from the IRanges package and is used by several other packages (eg. Rsamtools) to read in bam files.
Simply cbind-ing a column to the DataFrame object will change it to the more conventional data.frame class.
So, instead of
cbind(object1,newcolumn)
do:
cbind(object1,DataFrame(newcolumn))
to ensure that the result is still in the DataFrame class.
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